In this cross-sectional study, after adjusting for confounding factors such as sex, age, race, marital status, education level, smoking status, poverty rate, carbohydrate intake, BMI, diabetes, hypertension, C-reactive protein, triglycerides, total cholesterol, serum uric acid, and dietary selenium supplement intake, we confirmed the reliability of the significant negative correlation between dietary selenium intake and the incidence of CKD. The gene discussed is CRP; the disease is Hypertension.