Specifically, our analyses did not observe a significant difference in the rates of change in CSF Aβ42 or tau proteins between four cognitive trajectories (Figures 4G,H; Supplementary Figures S2G,H), indicating that amyloid accumulation or tau aggregation (CSF-based measures) may have reached a plateau at the MCI and mild dementia stages of the disease. The gene discussed is MAPT; the disease is dementia.