IL10 and neoplasm: Based on the findings of the tissue residency of TRM cells in the model of tumor implantation and allograft transplantation, it is conceivable that chronic antigen presentation in tissues contributes to the maintenance of multifunctional TRM cells unless the amount of cognate antigens is increased, such as the proliferation of cancer cells expressing MHC class I loaded with tumor antigens, or immune evasion strategies, such as release of immunosuppressive IL-10 or downregulation of MHC class I loaded with tumor antigens, are established in the tumor microenvironment [131].