CD8A and hepatocellular carcinoma: However, in the liver microenvironment, along with HBV-specific CD8+ TRM cells, non-specific CD8+ TRM cells cause apoptosis in hepatoma cells in an MHC class I-independent manner [193], suggesting that chronic inflammation induced by the battle between HBV-specific CD8+ TRM cells and HBV-infected cells leads to deleterious tissue damage.