This study, through a systematic literature review and meta-analysis, delved into several potential risk factors for postoperative incision infection in colorectal cancer, including a BMI of ≥24 kg/m2, diabetes, preoperative low albumin levels, the method of laparoscopic surgery, preoperative malnutrition, and surgical duration exceeding 3 h. The gene discussed is ALB; the disease is nutritional deficiency disease.