The ir-AIHA symptoms are defined according to the criteria defined by Leaf et al.:1) Sudden decrease in hemoglobin by greater than 2g/dL; 2) at least two Laboratory features of hemolysis (elevated serum lactate dehydrogenase; increased reticulocyte percentage or absolute count; low or undetectable serum haptoglobin; the presence of spherical cells on peripheral blood smears); 3) AIHA occurs after ICIs initiation; 4) exclusion of other causes of anemia; 5)ICIs treatment is considered to be the most likely cause of AIHA (47). The gene discussed is HP; the disease is anemia (phenotype).