Several hereditary genetic variations, found in approximately 5-20% of different cancer types, are associated with pathogenic variants of genes, such as BRCA2 and ATM. In PCa, pathogenic germline variants of the TP53 gene have been described with a relative risk of 4.7-8.6, which is comparable to the frequencies described for those genes (6). This evidence concerns the gene TP53 and posterior cortical atrophy.