PPARGC1A and cancer: In addition, a recent meta-analysis using the TCGA pan-cancer database and patients selected for P72R heterozygosity reported that 31% (127/409) of heterozygotes had lost the P72 allele in the corresponding tumor tissue (22), indicating that the G allele is preferentially selected for tumor development, possibly due to enhanced p73-induced apoptosis (16) and the modulation of tumor metabolism by regulating PGC-1α (23).