Moreover, several clinical studies have identified elevated levels of numerous inflammatory markers, including CRP, TNF-α, IL-1RA, sTNFR1, and sTNFR2, along with elevated serum NF-κB levels, in patients with DPN compared to patients with T2DM without neuropathy, suggesting that patients with DPN exhibit a more pronounced inflammatory response (96–98). The gene discussed is TNF; the disease is neuropathy.