ITGB4 and cancer: Among these genes are key players in cell cycle regulation and cancer (CDK3 and COL7A1), upregulation of transmembrane receptor involved in tumorigenesis and invasiveness (ITGB4); (Li et al., 2017), and genes involved in inflammation and tissue remodeling (S100A9 and PLOD1); (Rader et al., 2008; Lim et al., 2016; Qi and Xu, 2018).