Several histone deacetylases (HDACs), including HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, and HDAC8, play vital roles in PF progression (Shan et al., 2008; Pang and Zhuang, 2010; Huang et al., 2013; Khalil et al., 2015; Rubio et al., 2019; Zhang et al., 2020; Jeong et al., 2022; Hua et al., 2023). This evidence concerns the gene HDAC6 and pemphigus foliaceus.