Of note, the expression of PCK2 rather than other gluconeogenic enzymes (PCK1, Fructose-1,6-bisphosphatase 1, glucose-6-phosphatases) were significantly increased by glucose restriction (Figures 1B, C), indicating that PCK2-mediated metabolism might be required for NSCLC cells to adapt to a low glucose environment. Here, G6PC1 is linked to non-small cell lung carcinoma.