Importantly, the expression of cleaved caspase-3 and the number of TUNEL positive cells were increased in both A549-shPCK2 and H1975-shPCK2 tumor tissues (Figures 5I–K), confirming that loss of PCK2 promotes apoptosis in NSCLC cells in vivo in the low glucose. Here, CASP3 is linked to non-small cell lung carcinoma.