Curcumenol significantly increased the expression levels of HMOX-1 and transferrin but decreased the expression levels of GPX4, SLC40A1, SLC7A11, FTH1, Nrf2, and glutaminase in lung cancer cells, resulting in elevated ROS levels and decreased GSH levels, ultimately inducing ferroptosis in lung cancer cells. The gene discussed is GLS; the disease is lung carcinoma.