Brusatol induces ferroptosis through the FOCAD-FAK signaling pathway to inhibit lung cancer. And it inhibits NSCLC by enhancing the tricarboxylic acid cycle as well as Complex I activity within the mitochondrial electron transport chain, thereby increasing the susceptibility of NSCLC cells to ferroptosis induced by cysteine deprivation. This evidence concerns the gene FOCAD and lung carcinoma.