CDKN2A and chronic kidney disease: Due to the high levels of chronic inflammation and oxidative stress in patients with chronic kidney disease (CKD), which can lead to the accumulation of aging cells, researchers isolated BMSCs from CKD mice and detected DNA damage and cell aging, and found that the expression of the LMNA gene and prelamin A increased, whereas metformin treatment for 72 h resulted in a reduction in their expression, shown by the upregulation of CDKN2A expression and SASP.