CASP1 and liver dysplastic nodule: Through 16S rRNA analysis, we found that TA modulated gut microbiota dysbiosis and reduced the abundance of Gram-negative bacteria to reduce the production and release of LPS, thereby ameliorated impairments in the intestinal mucosa barrier, inhibited the NLRP3/ASC/Caspase-1 signaling pathway and further repressed the impact of inflammation on renal interstitial fibrosis in DN mice (Figure 7).