This can help to elucidate the mechanism of TA in ameliorating renal interstitial fibrosis by modulating gut microbiota dysbiosis, ameliorating impairments in the intestinal mucosa barrier, reducing LPS release into blood, inhibiting NLRP3/ASC/Caspase-1 signaling pathway, and repressing renal inflammation in DN mice. The gene discussed is CASP1; the disease is liver dysplastic nodule.