Several publications have reported that theAPOE e4 genotype is associated with COVID-19 susceptibility and severity (Numbers and Brodaty 2021;Kuoet al., 2020a,2020b).APOE e4 is a known risk factor for dementia, which has been replicated many times (Liuet al., 2013;Safieh, Korczyn, and Michaelson 2019;Emraniet al., 2020). The gene discussed is APOE; the disease is dementia.