TRPC6 and Cognitive impairment: In addition, several recent studies have found that transient receptor potential canonical channel 6 (TRPC6) (53) and histidine metabolism (54) may be potential therapeutic targets for preventing cognitive impairment caused by hypoglycemia events, while verapamil (55), ketogenic diet (56), niacinamide mononucleotide (57), and pyruvate (58) may be effective measures for alleviating brain injury caused by hypoglycemia.