This study highlights the association of HER-2 status in gastric and gastroesophageal junction carcinomas with specific clinicopathological features. Our findings indicate that HER-2 positivity is notably higher in patients at the extremes of age, as well as those with tubular adenocarcinoma and papillary adenocarcinoma, and moderately to poorly differentiated tumors. This evidence concerns the gene ERBB2 and gastric tubular adenocarcinoma.