For cannabis use, for example, Colizzi et al. (2015) in a case (FEP patients)-control study point to the impact of lifetime cannabis use on the susceptibility to developing a psychotic disorder, as well as the propensity for experiencing psychosis-like symptoms and cognitive alterations, which varies depending on the DRD2 rs1076560 genotype (a gene that encodes the D2 subtype of the dopamine receptor). This evidence concerns the gene DRD2 and psychotic disorder.