The risk coefficients were calculated from the correlation coefficients of the six hub CRC-PM-DEGs with the following formula (Figure 3B): CRC-PM-RS = THBS2*0.27+ANXA2*0.22+RAB13*0.18+SYK*0.06-USP11**0.5-PITX2*0.02. This evidence concerns the gene SYK and colorectal carcinoma.