Zhu et al’s study in breast cancer also showed that RAB13 controlled the C-X-C chemokine receptor type 1/2 (CXCR1/2) membrane translocation to make tumor cells to interact with tumor-associated macrophages (42), indicating RAB13 mediated interaction of tumor cells and macrophages in different cancers. This evidence concerns the gene CXCR1 and breast cancer.