Our study found a high density of immune cells and high expression of CD47 in the IM region, suggesting that the anti-tumor immune ability of immune cells may be inhibited, and also proved that the immunosuppressive state of the IM region of NSCLC tumors, and proposed that this immunosuppressive state may be related to the abnormal participation of B cells and T cells in the high density of E-TLS during TLS maturation in the IM region. Here, CD47 is linked to neoplasm.