XCL1 and neoplasm: Some studies have demonstrated that by inducing the Warburg effect in the tumor microenvironment (TME), activated C-X-C motif chemokine ligand 1/2 (CXCL1/2) binds to C-X-C motif chemokine receptor 2 (CXCR2), recruiting MDSCs and other cells, thereby fostering tumor growth and immune escape (58).