Encodes protein with serine-type endopeptidase and tumor necrosis factor binding activity, predicted to be involved in endodermal cell differentiation, positive regulation of tumor necrosis factor production, and proteolysis. Biomarker of COVID-19, aortic aneurysm (multiple), arthritis (multiple), breast cancer, and female reproductive organ cancer (multiple). The gene discussed is TNF; the disease is aortic aneurysm.