Deficiency in GADD45 expression has been associated with autoimmune disease (42), and the increased expression of GADD45G through administration of IL-27, has been shown to attenuate Th2-mediated allergic response possibly through the activation of the p38 MAPK pathway (43), a pathway that was found to be enriched among DEGs in CD4+ T cells in EoD. Here, IL27 is linked to autoimmune disease.