In EoE, we observed upregulation of IFNG in CD4+ T cells; upregulation of IER2 in B and CD8+ naïve T cells; upregulation of EGR1 in three level one cell types (B, CD4+ T, and CD8+ T cells) and several level two cell types, including naïve CD8+ T cells and CD4+ TCM cells, and upregulation of both EGR3 and EGR4 in B cells. This evidence concerns the gene CD4 and eosinophilic esophagitis.