The study found that when TYRO3 inhibits ferroptosis by regulating ferroptosis pathways such as NRF2, Xc system, tumor cells express high resistance to anti-PD-1/PD-L1 therapy (109).In addition, IFN γ released by CD8(+)T cells has been found to promote ferroptosis by acting on SLC3A2 and SLC7A11 on cancer cells, which also enhances anti-tumor immunotherapy against PD-L1 (110). The gene discussed is NFE2L2; the disease is neoplasm.