Superparamagnetic iron oxid spio-serum can effectively induce lipid peroxide and produce a large amount of toxic ROS by reducing the expression of the ferroptosis related proteins SLC7A11 and GPX4 in OVCA cells, play synergies with p53 and promote the occurrence of ferroptosis in ovarian cancer cells (77). This evidence concerns the gene TP53 and ovarian carcinoma.