NFE2L2 and neoplasm: For example, research has discovered that NRF2 can govern the ferroptosis of tumor cells through many downstream targets such as GPX4 channels (32, 33), HMOX1 (34), ferritinophagy activating proteins (ATG5 etc.)(31), while NRF 2 has also been reported to be connected with the prognosis of tumors (35).