These findings were discordant with other studies conducted by Nassar et al., Leyla et al., Solanki et al., Xu et al., Jana et al., and Fatma et al., where there was a strong correlation between COX-2 expression and lymph node metastases, which may recommend that COX-2 overexpression is highly correlated with aggressive characteristics and unfavorable breast cancer prognostic factors. Here, PTGS2 is linked to breast cancer.