In the present study, out of 39 cases with lymph node metastasis, 24 cases (64.9%) showed COX-2 positivity, which also revealed no statistically significant association between the expression of COX-2 and lymph node metastasis, as the p-value is 0.260. This evidence concerns the gene PTGS2 and metastatic malignant neoplasm in the lymph nodes.