For example, studies employing genetically modified mouse models and adoptive transfer of immune cells consistently demonstrate adverse roles of immune cells: deletion of the CCR2 monocyte receptor [38,39], deficiency of T- and B-cells [40,41], and increased immunosuppressive regulatory T-cells [42,43] all show protective effects against AngII-induced hypertension. The gene discussed is CCR2; the disease is Hypertension.