The current study showed that the addition of EA to HBSS significantly increased plc and pfoA expression by ATCC3624, suggesting that EA is one trigger (there may be others) used by type A strains to sense the presence of muscle cells, i.e. during gas gangrene, sensing of EA signals this bacterium to its presence in an environment containing muscle cells, so it becomes beneficial to increase toxin production for obtaining more nutrients from those host cells. This evidence concerns the gene HSPG2 and gas gangrene.