For instance, the Nuclear factor κB (NF‐κB) mediates the secretion of high levels of proinflammatory cytokines, including interleukin 6 (IL‐6) in the mouse HGPS models LmnaG609G/G609G and Zmpste24−/−. This evidence concerns the gene ZMPSTE24 and Hutchinson-Gilford progeria syndrome.