Recently, our group described the role of the NLRP3‐inflammasome, a well‐known multiprotein complex important for the maturation of IL‐1β and IL‐18, on the pathophysiology of HGPS both in human fibroblasts from patients and Zmpste24−/− mice. This evidence concerns the gene ZMPSTE24 and Hutchinson-Gilford progeria syndrome.