In the current study, we provide evidence demonstrating that inhibition of the NLRP3‐inflammasome complex in both human cells and in a mouse model of HGPS with dapansutrile, a safe NLRP3 inhibitor in human, improved cell survival and morphology, reduced inflammation and progerin levels and decreased senescence and SASP markers. The gene discussed is LMNA; the disease is Hutchinson-Gilford progeria syndrome.