Because, other than in models carrying mutations in Tsc1, in models with Tsc2 aberrations, epilepsy is not found (von der Brelie et al., 2006) and not even predisposition to hyperexcitability is seen at early postnatal stages (Bassetti et al., 2020), this model allowed studying the occurrence of cognitive impairment independent of epileptic potential. Here, TSC1 is linked to Cognitive impairment.