Several staging protocols and scoring systems such as the Barcelona Liver Cancer Staging system, China Liver Cancer Staging Programme, Tumor Node Metastasis staging system, and bilirubin, albumin (ALB), Lens culinaris agglutinin A–reactive fraction of alpha-fetoprotein (AFP), and des-γ-carboxy prothrombin score are in use [6]. The gene discussed is F2; the disease is liver cancer.