Moreover, knocking down ALKBH5 or using Ena15 or Ena21 to inhibit cell proliferation in glioblastoma-derived cell lines results in decreased cell populations in the synthetic phase of the cell cycle, increased m6A RNA levels, and stabilization of FOXM1 mRNA [126].The significance of compounds 2-(2-hydroxyethylsulfanyl)acetic acid (RD3) and 4-[(methyl)amino]-3,6-dioxo (RD6) as inhibitors of ALKBH5 has also been recognized. The gene discussed is ALKBH5; the disease is glioblastoma.