Although scarce data is available in pediatric populations, recent findings pinpoint that delayed insulin response in children with obesity is mirrored in worsen metabolic profiles (e.g., higher HOMA-IR scores and triglyceride content, lower HDL cholesterol) [6], oxidative stress and inflammasome activation [7], as well as altered metal homeostasis [8]. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.