Obesity stimulates cholesterol metabolism toward the production of bile acids to promote fat absorption [27], as well as the production of sex hormones through a complex meshwork of interrelated mechanisms, such as secretion of gonadotropin-releasing hormone, over-expression of adrenocorticotropic hormone, and reduction of sex hormone-binding globulin levels [28]. Here, SHBG is linked to obesity due to melanocortin 4 receptor deficiency.