Our results showed that combining heme and HO-1 with IL-6 had the best diagnostic potential for AAA (AUC; 0.87, 95% CI 0.83–0.91), with a sensitivity of 80% and specificity of 79% leading to a significant improvement of the previous models with GDF15 + CSTB and IL-6 alone. This evidence concerns the gene IL6 and triple-A syndrome.