SRSF2 and cyclic hematopoiesis: However, a striking exception to this pattern was observed in SRSF2-mutant CH, in which large clones were unexpectedly associated with longer telomere length (P = 2.2 × 10−6, β = 1.36 (0.81–1.91)), suggesting that SRSF2 mutations may mediate telomere elongation in CH.