In the past few years, alterations in the sequestered OFF state stability by DCM-causing mutations have been observed for two mutations in myosin heavy (E525K) and light chains (D94A in RLC); both mutations were found to result in stabilization of the SRX state (Rasicci et al, 2022; Yuan et al, 2022; Duno-Miranda et al, 2024), which is predicted to lead to hypocontractility due to reduced number of myosin heads available for force production. Here, MYH14 is linked to familial dilated cardiomyopathy.