GPM6B and central nervous system cancer: Notably, RSL3 induced widespread depletion of the astrocyte-like signature in transformed glioma cells across patient samples, including several genes with important metabolic functions, such as FABP7 (fatty acid binding protein 7), involved in fatty acid and mitochondrial metabolism, DBI (Diazepam Binding Inhibitor, Acyl-CoA Binding Protein) involved in lipid metabolism, and GPM6B (glycoprotein M6B), membrane proteolipid with important roles in membrane trafficking (Fig. 7I, Dataset EV9).