IDH1 and central nervous system cancer: Notably, the IDH-mutant glioma we tested also contained quiescent AC-like glioma cells that were selectively depleted by RSL3, although effects on the metabolic signatures were different, suggesting that sensitivity to ferroptosis is mechanistically distinct in IDH-mutant gliomas, possibly related to the effects of the IDH-mutation on cellular metabolism (Karpel-Massler et al, 2017; Fack et al, 2017).