FGFR3 and neoplasm: Most studies suggested that elevated IRTKS expression or the activated fusion gene FGFR3-BAIAP2L1 promoted tumor growth and progression by activating FGFR3 (Nakanishi et al, 2015), epidermal growth factor receptor (EGFR) signaling (Wang et al, 2013), and known membrane protrusions.