INS and type 2 diabetes mellitus: Among the possible mechanisms involved, increased oxidative stress in pancreatic beta-cells (Hoyeck et al. 2022; Jiang et al. 2021; Loiola et al. 2016; Marroqui et al. 2018; Park et al. 2020) or decreased insulin production (Hoyeck et al. 2022; Pavlikova et al. 2019, 2023) emerge from the literature in connection with type 2 diabetes development.