Interestingly, the microtubule localization of Drp1(-/17) has been associated with phosphorylation by cyclin-dependent kinases, where Cdk1 leads to Drp1(-/17) microtubule dissociation, while CDK5 mediates microtubule association of Drp1(-/17) during interphase, suggesting regulation of the subcellular distribution of different splice variants during the cell cycle (Strack et al, 2013), which requires further investigation in the context of cancer and differential Drp1 variant expression. This evidence concerns the gene CDK5 and cancer.