While prior work in Kras mutant pancreas cancers showed that complete knockdown of Drp1-mediated fission leads to abrogated hexokinase activity, decreased glycolysis and proliferation, and loss of mitochondrial function (Nagdas et al, 2019), we find that a more nuanced decrease in fission associated with Drp1(-/17) expression enhances mitochondrial respiratory function. Here, DNM1L is linked to digestive system neoplasm.