CDK12 and ovarian cancer: As such, aberrant expression of RNA splice factors such as SRSF3 is associated with ovarian cancer (He et al, 2011; Zhu et al, 2018), and we find that Drp1(-/17) is more strongly expressed in tumors with documented CDK12 mutations (Appendix Fig. S8B), a cyclin-dependent kinase that has been associated with regulation of the spliceosome (Tien et al, 2017).