Niclosamide's ability to uncouple mitochondrial phosphorylation, damage mitochondria in tumor cells, trigger apoptosis, and suppress the activities of multiple oncogenic pathways, including and regulating different tumor signaling pathways like Wnt/b-catenin, mTORC1, JAK/STAT3, NF-kB, and Notch pathway, has been linked to its anticancer activity8,12,21,27. This evidence concerns the gene NFKB1 and neoplasm.