Niclosamide inhibited Wnt/b-catenin pathway activation, decreased downstream b-catenin signaling, decreased S100A4 mRNA and protein expression, and had antiproliferative effects in colorectal cancer HCT-116 cells, human hepatic cancer cell lines (HepG2), and mouse liver metastasis21–23. Here, S100A4 is linked to colorectal cancer.