A recent study showed that upregulation of HOXC10 activates PI3K/AKT signal transduction to induce glioblastoma cell proliferation and lead to poor prognosis in glioblastoma.14 In breast cancer, suppressing the function of HOXC10 may be a potential strategy to overcome chemotherapeutic resistance.15 Metastasis is the main cause of low survival rates in cancer patients. This evidence concerns the gene AKT1 and cancer.