In the local tumor site and the TDLNs, MDSCs decomposed arginine and tryptophan, which are necessary for T-cell proliferation, eventually leading to the T-cell arrest in the G0 phase, and produce NO to inhibit the JAK3/STAT5 signaling pathway to reduce the expression of MHC II molecules, finally resulting in the apoptosis of T cells [36]. Here, JAK3 is linked to neoplasm.