INS and metabolic syndrome: Metabolic syndrome is characterized by a cluster of conditions, including obesity, insulin resistance, and dyslipidemia, and is intimately linked to chronic inflammation.355 The prevalence of metabolic syndrome rises by approximately 5% in men and 9% in female with each 1 mg/dL increase in serum uric acid concentration.356 Elevated serum uric acid levels have been shown to impair insulin sensitivity, thereby contributing to the development of insulin resistance.