Moreover, additional genetic alterations in hyperuricemia and gout associated with PDZK1 likely occurs through its modulation of the apical membrane localization of URAT1.55 Research has shown that individuals with renal hypouricemia and loss-of-function mutations in URAT1 demonstrate incomplete responses to both pyrazinamide and uricosurics, resulting in average concentrations reaching 0.93 mg/dL.185. This evidence concerns the gene SLC22A12 and hypouricemia, renal.