Chronic hyperuricemia is associated with pancreatic β-cell dysfunction, which is a critical component of type 2 diabetes.4 Research indicates that the likelihood of developing diabetes rises by 6% with each 1 mg/dL increment in uric acid concentration.240 Uric acid has been observed to adversely affect β-cells, resulting in impaired insulin secretion and decreased functional β-cell mass. Here, INS is linked to diabetes mellitus.