This impairment may be influenced by inherited renal transport factors or a reduced estimated glomerular filtration rate (eGFR).102,189,320,330 In patients with lower eGFR levels, uricosuric agents may not be as effective, necessitating the use of alternative agents with different mechanisms of action.379–381 Benzbromarone, another potent uricosuric drug, acts by inhibiting URAT1 and GLUT9.328,382 Emerging evidence linking hyperuricemia to cardiovascular and metabolic comorbidities has spurred the development of novel agents. This evidence concerns the gene SLC22A12 and hyperuricemia.