Infection of organoid cells generated from a transgenic Lgr5-mOrange reporter mouse line (Fazilaty et al, 2021; Reichmuth et al, 2021Preprint) confirmed the up-regulation of Lgr5-driven mOrange expression (Fig 1H–J) and confirmed that Lgr5 expression is induced by H. pylori at the transcriptional level. The gene discussed is LGR5; the disease is infection.