LGR5 and cancer: Lgr5 marks cancer stem cells that give rise to both corpus and antrum/pyloric gastric cancer in mice (Leushacke et al, 2017; Tan et al, 2020; Fatehullah et al, 2021), recapitulating the dominant gastric sites at which human non-cardia gastric cancer arises (Kim & Choi, 2019).