Accordingly, SJ-155, whichexhibited very little SIRT1/2/3 inhibition, also demonstrated veryweak inhibitory effects on DLBCL cell lines, supporting that the inhibitionof SIRT1/2/3 is important for SJ-106C’s effect in DLBCL cellsand the quaternary ammonium used is not toxic. The gene discussed is SIRT1; the disease is diffuse large B-cell lymphoma.