They play keyroles in regulating metabolism, stress responses, and aging processes,and are considered therapeutic targets for various diseases.9 The mitochondrial sirtuins SIRT3, SIRT4, andSIRT5 have emerged as potential therapeutic targets for diseases suchas metabolic disorders and cancers.10 Amongthe seven sirtuins, only SIRT3 was broadly required for the growthand survival of DLBCL cells.6 Here, SIRT3 is linked to metabolic disease.