DDIT3 and diffuse large B-cell lymphoma: We recently identified the mitochondrial sirtuin, SIRT3, amasterregulator of mitochondrial stress metabolism, as a critical driverof DLBCL growth and survival through its role in promoting glutaminolysis.6 Of note, highly active mitochondrial glutaminolysisand oxidative phosphorylation are associated with DLBCL resistanceto current therapies including R-CHOP, venetoclax, and ibrutinib.5,7,8 Hence, a potent SIRT3 inhibitorhas the potential to significantly improve the efficacy of DLBCL treatments.