NIN and infection: Does not make infections 3 (DMI3) detects the calcium signal and activates IPD3/CYCLOPS and DELLA, which further induce downstream transcription factors nodulation signaling pathway 1 (NSP1), nodulation signaling pathway 2 (NSP2), nodule inception (NIN), NIN-like protein 2 (NLP2), and rhizobium-directed polar growth (RPG).