In addition, differential gene expression analysis of aggregated pseudobulk MPCs from SB225002- and vehicle-treated P10-MI hearts demonstrated a significant reduction in the expression of proinflammatory genes (Fos and Jun) and an increase in the expression of reparative genes (Fn1 and Trem2) following CXCR2 inhibition (Supplemental Figure 12, A and B and Supplemental Table 18). The gene discussed is CXCR2; the disease is myocardial infarction.