For instance, the proinflammatory genes Jun (36) and Prdx5 (37) exhibited the highest representation in CCRNs specifically in the S100a9+Ly6c+ C6 cluster, in which the SNPs associated with CAD and hypertension were also notably enriched (Figure 3D and Supplemental Figure 5, A and B). Here, S100A9 is linked to coronary artery disorder.