S100A9 and myocardial infarction: In summary, our scRNA-Seq analysis demonstrated that the reduction in the proportion of the proinflammatory subpopulation and the increase in the proportion of the reparative subpopulation, coupled with the differential expression of the corresponding functional genes, collectively contributed to the enhanced reparative potential in hearts after P10 MI hearts upon targeting S100a9+Ly6c+ IMos.