NFE2L2 and metabolic dysfunction-associated steatotic liver disease: To determine whether or how the Nrf2/HO1/TP axis is affected in MASLD, we leveraged both the Duke MASLD patient bulk RNA-Seq dataset (GSE213623) and the publicly available snRNA-Seq dataset (GSE174748) to compare expression levels of NFE2L2 (the gene that encodes Nrf2) and HMOX1 in whole liver tissue and hepatocyte populations of human livers with and without MASLD, respectively.