To determine whether (and how) changes in hepatocyte Hedgehog activity influence MASLD progression, we fed Smofl/fl mice a metabolic dysfunction–associated steatohepatitis–inducing (MASH-inducing) diet for 6 weeks and used viral vectors to delete Smo selectively in hepatocytes during the final week. This evidence concerns the gene SMO and metabolic dysfunction-associated steatotic liver disease.