CASK and colorectal cancer: Specifically, the short MADD-4 isoform (MADD-4B) activates UNC-40/DCC (deleted in colorectal cancer) signaling, recruiting an intracellular postsynaptic scaffold composed of FRM-3, a FERM domain protein, and LIN-2/CASK (Tu et al., 2015; Zhou et al., 2020).