MAS1L and metabolic dysfunction-associated steatohepatitis: While the primary driver of hepatic steatosis is fat accumulation in the liver, the progression of MASL to MASH is influenced by a wide variety of factors, including genetics, inflammation, oxidative stress, mitochondrial malfunction, endoplasmic reticulum (ER) stress, lipotoxicity, insulin resistance, and gut dysbiosis (3, 13, 14).