By contrast, signals upregulated in HKO livers were more heterogeneous, including signals related to HSC senescence and death and quiescence — chemerin (64, 65), BMPs (66–68), and CALCR (69); signals classically associated with liver fibrosis (TGF-β and PDGF); and signals linked to hepatocyte regeneration and death prevention — TWEAK (70) and NOTCH (Supplemental Figure 5, D and E). This evidence concerns the gene TNFSF12 and Hepatic fibrosis.