Additionally, human iPSC-derived neural cells carrying distinct pathogenic SCN1A variants have recapitulated electrophysiological and molecular perturbations in DS (Sun et al., 2016; Schuster et al., 2019b; Maeda et al., 2016; Jiao et al., 2013; Higurashi et al., 2013). Here, SCN1A is linked to Dravet syndrome.