While it is now clear that the distinct features in DS are associated with a reduced sodium current density in Nav1.1 haploinsufficient interneurons and a disinhibition of the cortical network (Cheah et al., 2012; Schuster et al., 2019b; Ogiwara et al., 2013), the underlying epigenetic mechanisms are poorly understood. The gene discussed is SCN1A; the disease is Dravet syndrome.